Integration of Individual Residential Histories into Cancer Research (R21) PA-17-295 and (R01) PA-17-298

Sponsor:

NIH / NCI

Deadline:

Standard R01 dates apply

Standard R21 dates apply

Summary:

The purpose of this Funding Opportunity Announcement (FOA) is to support substantive investigation of the role of individual residential histories in cancer etiology and outcomes, and to encourage the development of complex analytical strategies in support of substantive investigation.

There is a growing recognition of the importance of residential histories – a record of an individual’s places of residence across his or her lifetime — in cancer research, as part of evolving cancer data ecosystem.  Residential history encapsulates a person’s multiple interactions with the social and physical environment that can result in lasting health impact and is an important factor in assessing the effects of exposures on disease onset, as demonstrated in focused studies.  Lifetime residential history records can reveal the variety of potential and actual exposures throughout person’s life including, but not limited to: neighborhood characteristics, physical conditions of housing, tobacco and alcohol consumption, food environments, chemical exposures to contaminants in water, soil, and air, accessibility to healthcare resources, and health disparities.

This FOA is expected to engage scientists from a range of disciplines, including epidemiology, statistics, geospatial science, computer science, demography, decision science, and behavioral science, to effectively integrate individual residential histories into cancer research.

Geospatial expertise is essential for generating new knowledge about the residential context relative to cancer risk, etiology, prevention, treatment, and outcomes. Computer science and informatics are crucial for the development of methodology that would ensure more precise matching of residential information and location (geocoding), improve linkage to automated data sources, and generate reliable lifetime residential histories. Cancer surveillance science, in conjunction with statistical, epidemiological, and medical expertise, is extremely important in answering substantial questions related to the use of lifetime residential histories in the analysis of cancer risk and cancer burden.

In addition, a combination of scientific expertise in demography and behavioral science in addressing the role of lifetime residential histories in the context of cancer can help facilitate more precise assessment of cancer disparities.

Eligibility:

N/A

Available Funding:

R01: Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years.

R21: The combined budget for direct costs for the two-year project period may not exceed $275,000. No more than $200,000 may be requested in a single year. The maximum project period is 2 years.

Link to Full RFP:

R01https://grants.nih.gov/grants/guide/pa-files/PA-17-298.html

R21https://grants.nih.gov/grants/guide/pa-files/PA-17-295.html

Clinical Trial Award – FY17 Peer Reviewed Medical Research Program (PRMRP)

Sponsor:

United States Department of Defense

Deadline:

Pre-Application (required): July 20, 2017

Application (by invitation only): October 26, 2017

Summary:

All applications for PRMRP funding must specifically address at least 1 of the 48 Topic Areas as directed by Congress and must be directly relevant to the healthcare needs of military Service members, Veterans, and/or beneficiaries.  Please see RFP for Topic Areas.

The PRMRP Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on a disease or condition addressed in at least one of the Congressionally directed FY17 PRMRP Topic Areas. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proofof-concept trials (e.g., pilot, first in human, Phase 0) to demonstrate feasibility or inform the design of more advanced trials, through large-scale trials to determine efficacy in relevant patient populations. All studies must be responsive to the healthcare needs of the military Service members, Veterans, and/or beneficiaries; however, the use of military or Veteran populations is not required.

Eligibility:

  • PIs at or above the level of Assistant Professor (or equivalent) are eligible to submit applications.
  • Funding from this award mechanism must support a clinical trial. Proposed projects may range from small proof-of-concept trials through large-scale, definitive trials.
  • Relevance to the healthcare needs of military Service members, Veterans, and beneficiaries is a key feature of this award. Applications are required to include an explanation of how the proposed project has military relevance.
    • PIs are encouraged to integrate and/or align their research projects with DoD and/or VA research laboratories and programs. Collaboration with the DoD or VA is also encouraged.

Available Funding:

Funding limit not defined; requested funding must be appropriate for the scope of work proposed/Maximum period of performance is 4 years

Link to Full RFP:

http://cdmrp.army.mil/funding/pa/FY17-PRMRP-CTA.pdf

Discovery Award – FY17 Peer Reviewed Medical Research Program (PRMRP)

Sponsor:

United States Department of Defense

Deadline:

Pre-Application (required):  July 19, 2017

Application (by invitation only):  August 2, 2017

Summary:

All applications for PRMRP funding must specifically address at least 1 of the 48 Topic Areas as directed by Congress and must be directly relevant to the healthcare needs of military Service members, Veterans, and/or beneficiaries.  Please see RFP for Topic Areas.

The intent of the PRMRP Discovery Award is to support innovative, non-incremental, highrisk/potentially high-reward research that will provide new insights, paradigms, technologies, or applications. Studies supported by this award are expected to lay the groundwork for future avenues of scientific investigation. The proposed research project should include a wellformulated, testable hypothesis based on a sound scientific rationale and study design.

The outcome of research supported by this award should be the generation of preliminary data that can be used as a foundation for future research projects to understand the mechanisms of initiation or progression and/or improving patient care for a disease or condition.

Eligibility:

  • Investigators at the level of postdoctoral fellow or clinical fellow (or equivalent) and above are eligible to submit applications.
  • Relevance to the healthcare needs of military Service members, Veterans, and beneficiaries is a key feature of this award. Applications are required to include an explanation of how the proposed project has military relevance.
    • PIs are encouraged to integrate and/or align their research projects with DoD and/or VA research laboratories and programs. Collaboration with the DoD or VA is also encouraged.

Available Funding:

Maximum of $200,000 for direct costs (plus indirect costs)/ Maximum period of performance is 18 months

Link to Full RFP:

http://cdmrp.army.mil/funding/pa/FY17-PRMRP-DA.pdf

Focused Program Award – FY17 Peer Reviewed Medical Research Program (PRMRP)

Sponsor:

United States Department of Defense

Deadline:

Pre-Application (required):  July 20, 2017

Application (by invitation only):  October 26, 2017

Summary:

All applications for PRMRP funding must specifically address at least 1 of the 48 Topic Areas as directed by Congress and must be directly relevant to the healthcare needs of military Service members, Veterans, and/or beneficiaries.  Please see RFP for Topic Areas. The PRMRP Focused Program Award mechanism is intended to optimize research and accelerate the solution for a critical question.

  • Projects must support a synergistic, multidisciplinary research program of at least four distinct but complementary projects addressing an overarching goal.
  • Projects should work together to answer critical questions, resolve differing hypotheses, and translate laboratory findings to clinical applications.
  • Projects may range from exploratory/ hypothesis-developing through small-scale clinical trials that together will address the overarching goal/question.
  • Research team of highly qualified, multidisciplinary project leaders should be led by a PI with demonstrated success in directing large, focused projects.

Eligibility:

  • The PI must be an independent investigator at or above the level of Full Professor (or equivalent).
  • The PI is required to devote a minimum of 20% effort to this award.
  • Project leaders for each of the complementary and synergistic research projects must be at or above the level of Assistant Professor (or equivalent).
  • Relevance to the healthcare needs of military Service members, Veterans, and beneficiaries is a key feature of this award. Applications are required to include an explanation of how the proposed project has military relevance.
    • PIs are encouraged to integrate and/or align their research projects with DoD and/or VA research laboratories and programs. Collaboration with the DoD or VA is also encouraged.

Available Funding:

The anticipated total costs budgeted for the entire period of performance will not exceed $10M / maximum period of performance is 4 years.

Link to Full RFP:

http://cdmrp.army.mil/funding/pa/FY17-PRMRP-FPA.pdf

The National Academy of Education/Spencer Dissertation Fellowship Program

Sponsor:

The National Academy of Education (NAEd)/Spencer Foundation

Deadline:

5 PM Eastern Time, Thursday, October 5, 2017.

Summary:

Through the dissertation fellowship, the National Academy of Education (NAEd) and Spencer seek to encourage a new generation of scholars from a variety of fields to undertake research relevant to the improvement of education. The NAEd and Spencer believe scholarly insight from many different disciplines can contribute to an understanding of education as a fundamental human endeavor and advance our ability to address significant current issues in education. Therefore, the NAEd/Spencer Dissertation Fellowship supports individuals whose dissertations show potential for bringing fresh and constructive perspectives to the history, theory, or practice of formal or informal education anywhere in the world.

Although the dissertation topic must centrally concern education, graduate study may be in any academic discipline or professional field. Fellowships have been awarded to candidates in anthropology, architecture, art history, communications, economics, education, history, linguistics, literature, philosophy, political science, psychology, public health, religion, and sociology. Eligibility is not restricted to these academic areas. Candidates should be interested in pursuing research on education once the doctorate is attained.

Eligibility:

Applicants need not be citizens of the United States; however, they must be candidates for a doctoral degree at a graduate institution within the U.S. The fellowship is not intended to finance data collection or the completion of doctoral coursework but rather to support the final analysis of the research topic and the writing of the dissertation. For this reason, all applicants must confirm via the online application that they will have completed all pre-dissertation requirements by June 1, 2018 and must provide a clear and specific plan for completing the dissertation within a one or two-year time frame.

Available Funding:

Up to 35 non-renewable fellowships will be awarded. Recipients of the fellowships will receive $27,500 to support completion of the dissertation. This amount must be expended within a time limit of up to two years and in accordance with the work plan provided by the candidate.

Link to Full RFP:

NAEd/Spencer Dissertation Fellowship Program Guidelines

Bernard F. and Alva B. Gimbel Foundation

Sponsor:

Bernard F. and Alva B. Gimbel Foundation, Inc.

Deadline:

Letters of inquiry are accepted an ongoing basis through the Foundation’s online application system.

The Foundation makes grant decisions in December and June.

Summary:

Environment

The Foundation supports efforts to address a range of environmental issues. Among these are initiatives aimed at combating climate change by reducing carbon emissions and increasing energy efficiency; ensuring access to clean air and water by preventing pollution and the use of toxic chemicals; and restoring the health of the oceans by promoting responsible fishing, fighting ocean pollution and preserving marine ecosystems. Funded organizations employ a variety of strategies including policy advocacy, litigation and other legal efforts, public education, grassroots campaigns, and market-based and economic incentives. Historically, the Foundation’s environmental funding has been focused on organizations whose efforts are national and international in scope. However, local initiatives to increase the sustainability and resiliency of New York City’s built environment are also of interest.

Criminal Justice

Funding in this area is focused on efforts to promote fair and effective criminal justice policies, to reduce recidivism, and to improve public safety. Among these are sentencing reform initiatives including repeal of mandatory minimum sentencing laws and increased use of alternatives to incarceration.

Economic Development

The Foundation’s funding in the area of economic development is aimed at increasing the number of living wage jobs in New York City and ensuring low-income workers’ access to those jobs. Support is provided for initiatives that help individuals, families and communities to achieve and sustain economic self-sufficiency; for advocacy efforts to advance effective economic and workforce development policies; and for a range of job training programs, with an emphasis on those geared toward long-term retention and advancement in specific employment sectors.

Reproductive Rights

The Foundation supports domestic programs that seek to protect women’s reproductive rights and increase access to reproductive health services. Funded initiatives include those working to achieve these goals through public education efforts, policy advocacy and legal advocacy. Also of interest to the Foundation are efforts to increase reproductive health training opportunities for medical students and healthcare professionals, as well as efforts to support them as public advocates for comprehensive reproductive healthcare.

Civil Legal Services

The Foundation supports efforts to reduce barriers to effective and unrestricted civil legal assistance through direct legal representation and policy advocacy. Support is provided for programs offering legal representation and training on a range of issues including education, employment and foster care. Funding is also provided for initiatives aimed at increasing the accessibility of legal services in underserved communities, as well as those that enhance the courts’ ability to effectively and efficiently process cases.

Eligibility:

Grants are made only to tax-exempt 501(c)(3) organizations.

Available Funding:

Not specified.

Link to Full RFP:

http://www.gimbelfoundation.org/HowtoApply.htm

Presidential Early Career Awards for Scientists and Engineers (PECASE)- NSF 17-537

Sponsor:

National Science Foundation

Deadline:

Full Proposal Deadline(s) (due by 5 p.m. submitter’s local time):

July 19, 2017-BIO, CISE, EHR

Third Wednesday in July, Annually Thereafter

July 20, 2017-ENG

Third Thursday in July, Annually Thereafter

July 21, 2017-GEO, MPS, SBE

Third Friday in July, Annually Thereafter

Summary:

PECASE: Each year NSF selects nominees for the Presidential Early Career Awards for Scientists and Engineers (PECASE) from among the most meritorious recent CAREER awardees. Selection for this award is based on two important criteria: 1) innovative research at the frontiers of science and technology that is relevant to the mission of NSF, and 2) community service demonstrated through scientific leadership, education, or community outreach. These awards foster innovative developments in science and technology, increase awareness of careers in science and engineering, give recognition to the scientific missions of the participating agencies, enhance connections between fundamental research and national goals, and highlight the importance of science and technology for the Nation’s future. Individuals cannot apply for PECASE. These awards are initiated by the participating federal agencies. At NSF, up to twenty nominees for this award are selected each year from among the PECASE-eligible CAREER awardees most likely to become the leaders of academic research and education in the twenty-first century. The White House Office of Science and Technology Policy makes the final selection and announcement of the awardees.

Eligibility:

A Principal Investigator (PI) may submit only one CAREER proposal per annual competition. In addition, a Principal Investigator may not participate in more than three CAREER competitions. Proposals that are not reviewed (i.e., are withdrawn before review or are returned without review) do not count toward the three-competition limit.

Available Funding:

Anticipated Type of Award: Standard Grant or Continuing Grant

Estimated Number of Awards: 450 per year

Anticipated Funding Amount: $222,000,000

This annual amount is approximate, includes new and continuing increments, and is subject to availability of funds.

Link to Full RFP:

https://www.nsf.gov/pubs/2017/nsf17537/nsf17537.htm?WT.mc_id=USNSF_25&WT.mc_ev=click

Dissemination and Implementation of PCORI-Funded Patient-Centered Outcomes Research Results and Products in Real-World Settings

Sponsor:

Patient-Centered Outcomes Research Institute (PCORI)

Deadline:

Letters of Intent due March 2, 2016 at 5:00 PM Eastern

Applications due June 6, 2016 at 5:00 PM Eastern

Summary:

PCORI is launching this funding initiative to support the dissemination and implementation (D&I) of patient-centered outcomes research/comparative clinical effectiveness research (PCOR/CER) results obtained from PCORI-funded studies. This PCORI Funding Announcement (PFA) provides awardees the opportunity to apply for funds to support dissemination and implementation of their research. PCORI recognizes that generating research evidence will be useful only if there is a commitment and strategic plan to disseminate and implement it within the context of other evidence. Through this funding announcement, PCORI seeks to fund projects designed to actively disseminate and implement the results of PCORI-funded studies that are informed and guided by established dissemination and implementation models and frameworks, in the context of real-world settings. This PFA is designed to help close the gap between evidence development and implementation of that evidence in practice.

PCORI’s objectives underlying this funding announcement are:

  • To provide PCORI awardees the opportunity to disseminate the important findings pertaining to the original PCORI research that can improve practice on a timely basis
  • To stimulate the development, application, and evaluation of D&I approaches that will increase the use and application of PCOR/CER research results, as well as products derived from PCORI funded studies, by diverse populations of end-users including patients, caregivers, providers, policy makers and other relevant stakeholders
  • To gain and apply generalizable knowledge from feedback and evaluation of dissemination and implementation strategies to better understand the barriers and facilitators of evidence dissemination and uptake, and to inform improvements in future D&I efforts and ensure applicability to a wide range of audiences
  • To explore the development, application, and evaluation of mechanisms for incorporating CER findings in decision making by diverse groups of stakeholders. This includes identifying best practices for approaching D&I in PCORI priority areas and with priority populations.

Eligibility:

PCORI Research Awardees: Recipients of PCORI research awards, including Broad PCORI Awards, Pilot Projects Program Awards, Targeted PCORI Awards, Pragmatic Clinical Study Awards, and PCORI-funded demonstration projects occurring within the Patient-Centered Clinical Research Network (PCORnet) infrastructure (e.g. ADAPTABLE, Obesity trials) are eligible to respond to this announcement. Applications associated solely with Eugene Washington PCORI Engagement Awards and Pipeline to Proposal Awards are not eligible for this funding announcement.

Organization: Applications may be submitted by a private-sector research organization, including any nonprofit or for-profit organization, and any public-sector research organizations, including any university or college hospital or healthcare system, laboratory or manufacturer, or unit of local, state, or federal government. The Internal Revenue Service must recognize all U.S. applicant organizations. Nondomestic components of organizations based in the United States and foreign organizations may apply, as long as there is demonstrable benefit to the U.S. healthcare system and U.S. efforts in the area of patient-centered research can be shown clearly. Organizations may submit multiple applications for funding. Individuals are not permitted to apply.

Personnel: A letter of support is required from the Principal Investigator (PI) of the original PCORI-funded research project if he or she is not the proposed PI of the current application

Available Funding:

Available Funds: Up to $2 million per cycle

Maximum Project Budget (Direct Costs): $300,000

Link to Full RFP:

http://www.pcori.org/sites/default/files/PCORI-PFA-2016-Cycle-1-Dissemination-Implementation.pdf

Assessment of Prevention, Diagnosis, and Treatment Options

Sponsor:

Patient-Centered Outcomes Research Institute (PCORI)

Deadline:

Letters of Intent due March 2, 2016 at 5:00 PM Eastern

Applications due June 6, 2016 at 5:00 PM Eastern

Summary:

Patients, caregivers, and clinicians often lack the appropriate evidence required to make the best choices regarding prevention, screening, diagnosis, monitoring, or treatment. Where therapies or technologies have been approved and marketed, there are often gaps in research comparing their effectiveness with that of other clinical options, and prior research may not have included outcomes that are important to patients and their caregivers. In addition, the existing evidence base may not be relevant for certain patient populations, such as those at the extremes of age or with multiple comorbid conditions.

For this particular PFA on the Assessment of Prevention, Diagnosis, and Treatment Options, PCORI seeks to fund investigator-initiated research that:

  • Compares the effectiveness of two or more strategies for prevention, treatment, screening, diagnosis, or management that are known to be efficacious but have not been adequately compared in previous studies; interventions without sufficient evidence of efficacy will be considered only when they are in reasonably common use. PCORI is particularly interested in studies that are conducted in typical clinical populations and that address the full range of relevant patient-centered outcomes (PCOs)
  • Addresses a high-priority evidence gap, as identified by prior systematic reviews, clearly defined gaps in clinical guidelines, or other credible evidence reviews
  • Investigates, among compared groups, factors that account for variation in treatment outcomes, with attention paid to demographic, biological, clinical, social, economic, or geographic factors, comorbidities, and other factors that may influence those outcomes; strategies may focus on patient populations with a single condition or involve patients with a range of conditions

For this PCORI Funding Announcement (PFA), proposed projects should address the comparison of specific clinical services or strategies that are clearly defined and can be replicated in other clinical settings with minimal adaptations or changes. PCORI does not encourage projects that have the primary goal of developing and testing decision aids or testing the use of lay personnel who perform ancillary services in healthcare settings.

Eligibility:

  • Applications may be submitted by any private-sector research organization, including any nonprofit or for-profit organization, and any public-sector research organization, including any university or college hospital or healthcare system, laboratory or manufacturer, or unit of local, state, or federal government.
  • The Internal Revenue Service must recognize all U.S. applicant organizations.
  • Nondomestic components of organizations based in the United States and foreign organizations may apply, as long as there is demonstrable benefit to the U.S. healthcare system and U.S. efforts in the area of patient-centered research can be shown clearly.
  • Organizations may submit multiple applications for funding.
  • Individuals are not permitted to apply

Available Funding:

Available Funds: Up to $32 million

Maximum Project Budget (Direct Costs): $2 million

Link to Full RFP:

http://www.pcori.org/sites/default/files/PCORI-PFA-2016-Cycle-1-Assessment-of-Options.pdf

Addressing Disparities

Sponsor:

Patient-Centered Outcomes Research Institute (PCORI)

Deadline:

Letters of Intent due March 2, 2016 at 5:00 PM Eastern

Applications due June 6, 2016 at 5:00 PM Eastern

Summary:

PCORI invites applications for clinical CER designed to evaluate and compare interventions intended to reduce or eliminate disparities in health and health care. Patients, caregivers, and clinicians often lack the appropriate evidence required to make the best choices regarding prevention, screening, diagnosis, monitoring, or treatment. Applications to the Addressing Disparities Program should focus on overcoming barriers that may disproportionately affect health outcomes or focus on identifying best practices for reducing disparities in target populations (racial and ethnic minority groups; low-income groups; residents of rural areas; individuals with special healthcare needs, including individuals with disabilities; patients with low health literacy/numeracy and/or limited English proficiency; and lesbian, gay, bisexual, and transgender [LGBT] persons).

The Addressing Disparities Program is interested in funding CER of evidence-based interventions aimed at reducing and eliminating disparities in health and health care. Interventions to reduce persistent disparities have been understudied and are multifactorial, complex, and context-specific. Often, evidence-based interventions have been shown to be effective in the general population but lack evidence for effectiveness in populations at risk for disparities. The Addressing Disparities Program is interested in studies that tailor and test these types of interventions in these populations.

Eligibility:

  • Applications may be submitted by any private-sector research organization, including any nonprofit or for-profit organization, and any public-sector research organization, including any university or college hospital or healthcare system, laboratory or manufacturer, or unit of local, state, or federal government.
  • The Internal Revenue Service must recognize all U.S. applicant organizations.
  • Nondomestic components of organizations based in the United States and foreign organizations may apply, as long as there is demonstrable benefit to the U.S. healthcare system and U.S. efforts in the area of patient-centered research can be shown clearly.
  • Organizations may submit multiple applications for funding.
  • Individuals are not permitted to apply

Available Funding:

Available Funds: Up to $8 million

Maximum Project Budget (Direct Costs): $1.5 million

Link to Full RFP:

http://www.pcori.org/sites/default/files/PCORI-PFA-2016-Cycle-1-Addressing-Disparities.pdf